Using longitudinal data from the Fragile Families and Child Wellbeing survey (N = 4,211), this study examines neighborhood disadvantage and perceptions of instrumental support among mothers with young children. The authors find that (a) living in a disadvantaged neighborhood is associated with less instrumental support, particularly financial assistance, from family and friends; (b) residential stability is associated with stronger personal safety nets irrespective of neighborhood quality; and (c) mothers who move to a more disadvantaged neighborhood experience a small but significant decline in perceived instrumental support compared with those who do not move. In interpreting these results, the authors suggest instrumental support may be either a cause or consequence of living in an advantaged neighborhood, but in either case, neighborhood and social network disadvantages go hand in hand. (Contains 4 tables.)