Distance education enabled by e-learning is at the forefront of university participation in an increasingly connected world. Physical, temporal, cultural and educational borders are becoming both less rigid and less predictable than ever before. The authors suggest, in this article, that university distance e-learning could and should allow universities to make a major contribution to lifelong learning in this networked world. However, just as lifelong learning and distance e-learning are subject to multiple interpretations and realizations, the role that universities might play in contributing to global lifelong learning is currently far from clear. Both distance education, as a mode of learning and teaching, and lifelong learning, as an aspiration and a policy, bring issues pertaining to the roles and values of universities into sharp focus. On the fluid, unpredictable landscape of global higher education are traced the imperatives driving distance e-learning and lifelong learning in order to discern the redrawing of borders that appears to be emerging. The parallels between unsettled territories and unresolved tensions in distance e-learning and lifelong learning will be highlighted. The authors suggest that distance e-learning could enable lifelong learning and that lifelong learning, broadly interpreted, should be a cornerstone of university strategy and activity in a world that is increasingly networked. (Contains 2 notes.)