Problem-based learning, or PBL, is a student-centered instructional approach that is derived from constructivist epistemology. It is based upon ill-structured real-world problems with the goal of strengthening and developing critical thinking and problem-solving skills in learners. Initially utilized in medical schools to strengthen diagnostic skills, the approach spread to disciplines such as education, business, architecture, and engineering. As the practice of PBL spread, adaptations of the process began to appear. Nonetheless, throughout these adaptations, integral components emerge as congruent: student-centered, ill-structured problems, multi-disciplinary focus, self-regulation, collaboration, reflection, and evaluation. In this environment, the role of the instructor shifts from didactic to a facilitator or tutor. This article will explore utilizing integral PBL concepts in the asynchronous online environment.