This article provides an overview of how Universal Design for Learning (UDL) applies to higher education. Illustrations of UDL implementation are made, using both campus models of systemic change and coursework exemplars. Start-up solutions and sample applications are summarized. The purposes of this article are to: provide an overview of UDL, including needs for and challenges to UDL in higher education; and identify start-up strategies and models for faculty implementation of UDL practices, addressing potential challenges to their use. (Contains 6 tables.)