Families' involvement in their children's science learning at home has numerous benefits, especially when they support children's self-initiated investigations. In a position statement on parental involvement in science education, the National Science Teachers Association (NSTA 2009) stresses the role of parents in the daily reinforcement of children's learning of science concepts and science process skills. It is important for families to realize that although young children may not internalize or fully understand scientific phenomena, they can begin to develop the foundational science concepts, skills, and methods necessary for becoming "scientifically literate and informed citizens". "Science at Home for Families" uses the National Science Education Standards (NRC 1996) as a framework for science content and scientific process skills universally taught during children's primary years. This article presents key concepts in four areas: (1) physical science; (2) life science; (3) earth/space science; and (4) personal health. For each area it offers home-based science learning activities, related questions, and resources for parents and children.