An extensive literature documents that a lower level of acculturation is associated with better health outcomes among U.S. immigrants, despite the many hardships these families face. It is likely that cultural practices and strong family networks contribute to this phenomenon, which has been termed the "healthy immigrant effect". This article examines the healthy immigrant effect among Latino families, the fastest-growing U.S. racial/ethnic group, and describes several health disparities that burden Latino children and families and exist alongside these favorable outcomes. The authors present 2 community-based programs as models that successfully reduce or eliminate disparities in the health and development of young Latino children, using family-centered interventions capitalizing on traditional cultural strengths.