When one considers the enormous cost of science laboratory buildings, it is no surprise that the stream of environmental consciousness that has swept through campuses has had a profound effect on the design and engineering of these complex buildings. Advancing technologies, government regulations and rising energy costs all are driving the push to design greener building systems. Although science and laboratory buildings are by far the most complex and energy-intensive buildings on campus, they also can be models of effective energy management, carbon-footprint control and sustainability. This article discusses some considerations when designing a sustainable and energy-saving science and laboratory building.