HIV/AIDS has changed drastically since the introduction of life-saving drugs known as highly active antiretroviral treatment. These same drugs have created a schism between the haves and the have-nots in society. The demographics of the disease have also changed alongside treatment. This article explores the changing face of HIV/AIDS in the 21st century by using the work of political scientist Harold Lasswell. Lasswell has provided a theoretical framework in which to view an epidemic that is deeply affecting communities of color. This framework further accentuates the need for social workers to do more work in the area of HIV/AIDS within communities of color.