High-risk alcohol, tobacco, and other drug (ATOD) use has been a persistent problem on college campuses despite decades of prevention programming. However, some universities may begin to experience a lower prevalence of high-risk behaviors, not because of education efforts, but because of generational changes in the incoming student population. This study examined the ATOD use of incoming students (n = 5,964) at a large, southeastern, public university over a 5-year period. The data demonstrated an overall decrease in incoming students' ATOD use, which may be connected to the defining characteristics of the Millennial generation--a need for structure, respect for authority, a tendency to follow rules and institutional policies, and an appreciation for the institution's increasing focus on academic rigor--as well as increased ethnic diversity of the generation. As increasing numbers of Millennials enter college, these results become critically important for prevention work and policy development. (Contains 5 tables.)