To consider how interdisciplinary P-20 partnerships increase college going among Chicano/Latino youth, the authors highlight evidence from the Educational Partnership Center (EPC), University of California, Santa Cruz, a P-20 partnership building academic achievement and college and career pathways. Three elements advance EPC effectiveness: collaborative governance structures sustaining shared vision, mission, and goals; innovating with data-driven decision making; and complementary theories aligning goals from childhood through college to careers. Three studies, guided by these theories, illuminate such effectiveness. (Contains 1 table and 1 figure.)