This article reviews the topic of college student suicide. Empirical and theoretical studies are reviewed. The research is presented in distinct sections. First, we present background information on college student suicide emphasized in a select number of cited literature reviews, followed by a review of a select number of key quantitative studies aimed at investigating risk factors and predictors of suicide among the college student population. Next, we discuss a select number of articles offering suggestions for the treatment and prevention of suicide based on the literature, including those articles that specifically explain developed prevention programs. Finally, obstacles to prevention are examined. Recommendations and future directions for research and practice are examined, which are particularly significant in light of tragic events on many different college campuses in recent years.