This study examined the relationships of adolescents' perceptions of parental and peer behaviors with cigarette and alcohol use in different neighborhood contexts. The sample included 924 adolescents (49% boys, 51% girls) 12-14 years of age whose addresses were matched with 1990 census block groups. Six neighborhood types were identified through a cluster analysis. The findings suggest that parental smoking was associated with increased adolescent smoking in suburban white middle socioeconomic status (SES) neighborhoods. Peer smoking was associated with increased adolescent smoking in rural neighborhoods. Parental monitoring was associated with decreased adolescent drinking in urban white high-SES neighborhoods and parental drinking was associated with increased adolescent drinking in urban white middle-SES neighborhoods, respectively. Peer drinking was associated with increased adolescent drinking in urban neighborhoods. This study demonstrates the importance of examining parental and peer influences on adolescent smoking and drinking in different neighborhood contexts.