At the national level, obesity and obesity-related illnesses are increasing dramatically. As with many other public health problems, some racial and ethnic populations are disproportionately affected. This article presents current information on the prevalence and consequences of obesity for racial and ethnic groups in the United States and evaluates race/culture-specific causes of obesity for these populations. After analysis of various interventions that attempt to address this problem, a full-spectrum, three-pronged model for eliminating racial and ethnic disparities in obesity is presented and discussed. It is argued that a comprehensive population model, with a balance between downstream, midstream, and upstream interventions is necessary. Examples of culturally appropriate interventions that address the behavioral, social, and environmental determinants of obesity at each of these levels are presented. Using the tools of sound theory, appropriate methods, and cultural sensitivity, health educators are in a unique position to provide leadership to this effort. (Contains 1 table and 1 figure.)