Neighborhood size and neighborhood frequency were orthogonally varied in two experiments on Italian nonwords. In Experiment 1, an inhibitory effect of neighborhood frequency on visual lexical decision was found: The presence of one high-frequency neighbor increased response latencies and error rates to nonwords. By contrast, no effect of neighborhood size and no neighborhood size x neighborhood frequency interaction were found. In Experiment 2, a facilitatory effect of neighborhood size on nonword naming was shown: Naming latencies were faster when nonwords had a large neighborhood. In the naming experiment, there was no effect of neighbors' frequency and no neighborhood size x neighborhood frequency interaction. An additional role for bigram frequency was found whereas syllable frequency did not give any independent contribution. These results further corroborate the view that, in a language with transparent orthography like Italian, despite a substantial contribution of sublexical print-to-sound mapping due to the language's high regularity/consistency, reading aloud of nonlexical material may benefit from the contribution of the lexical component.