Objective: This article builds on earlier discussions about college health research. The author suggests a 5-step framework that research practitioners can use to build models of practice that accurately address the needs of diverse campus populations. Methods: The author provides 3 illustrations, drawn from published research examining college women with eating-related concerns, making the case for the importance of the Eating Disorders Not Otherwise Specified Diagnosis; examining African American students' social adjustment, making the case for an innovative model of needs; and examining minority sexual orientation students' identity development, making the case for a specialized developmental model. Conclusions: Following the illustrations, the author offers implications for practice and limitations of the proposed framework. (Contains 1 table.)