Children with disabilities receive most of their support from families. While most family caregivers are mothers or fathers, grandparents are increasingly providing care for children with disabilities. In addition, family caregivers come from diverse cultural backgrounds that impact their views on disability. This paper reviews the literature on parent and grandparent caregivers of children with disabilities as well as the literature on parenting children with disabilities across cultures. Drawing from a literature review, the paper discusses emerging directions in intervention.