The strategies for breaking down the roadblocks and realizing the promise of active learning and inquiry instruction in the large class are being tested and publicized. Educators who have addressed the multitude of issues that underlie implementation of active-learning strategies in large-enrollment settings are conscientiously spreading the word to the science education community by presenting at conferences or publishing in science education journals. In this article, the authors focus on the large-class setting, providing an overview of tried-and-true approaches for incorporating active learning, ranging from the simple to complex. The authors highlight those that have been implemented in the lecture classroom itself, rather than those that make use of small-enrollment lab and discussion sections, or of virtual environments such as electronic bulletin boards and computer-based learning modules. Although some seemingly fearless individuals have adapted problem-based learning (PBL) or the case study method to large-class settings, the authors focus for the most part on strategies and activities that typically do not require such a radical reframing of current standard practice, and are therefore more readily accessible to most science educators.