Temperament refers to individual differences in two broad aspects of behavior: (1) emotional, motor, and attentional reactivity and (2) self-regulatory processes that modulate such reactivity. These individual differences are grounded in people's constitution and influence both stress reactions and patterns of coping. In this chapter, we examine how individual differences in temperament are conceptually linked to the development of coping and how this association is modulated by the maturation of brain systems underlying temperament. Finally, we argue about the possibility of improving children's coping abilities through intervention programs designed to foster self-regulation. (Contains 1 figure.)