The aim of this paper is to transform the necessity for "integrated ICT training" in study courses within universities into a possible action plan which indicates both the pros and cons of the use of IT in the strategies, services and products to be used from a cost point of view. This will enable an evaluation of the Return On Investment (ROI) using the new concept of Yield Index "e-lYI" (e-learning Yield Index), introduced in this study. The Yield Index "e-lYI" suggests an original way to evaluate the implementation of e-learning methodologies into campus based environments; still, the new index will help professionals involved in the management of the transition from the "classical" university structure to the innovative structure needed by the e-learning implementation. These results should interest any Faculty or University which is planning to introduce e-learning methodology to its didactic organization. In this study, a Pilot Course, delivered in "Blended" learning model, will be taken into consideration to estimate the costs. In the subsequent phase the ROI will be assessed for the Pilot course and compared to the ROI of a classical course by the use of "e-lYI". Furthermore, it would therefore be extremely interesting to consider the "e-lYI" in a University administration that decided to adopt an Open Source Learning Management Systems. Open Source, therefore, will be the final element of innovation and experimentation in the evaluation process. (Contains 4 tables.)