The clinical aspects and staff training needs for two substance use disorder (SUD) treatment programs that serve persons with co-existing disabilities are described. The article addresses SUD prevalence among persons with disabilities and the corresponding specialized treatment needs and accommodations that may be necessary. The philosophical orientations, demographic profiles, and treatment outcome data are presented. Considerations about staff training are reviewed, and strategies for implementing a comprehensive staff training program are discussed. (Contains 3 figures and 3 tables.)