Chrysalis is a weekly after-school drop-in group on O'ahu high school campuses for transgendered and questioning youth. Nine Chrysalis members, nine demographically matched TG youth, and five key informants participated in a study to evaluate program effectiveness in improving life skills and preventing HIV infection. Chrysalis members scored better than comparison group members in school participation, educational and career goals, self-esteem, friends and peer support, family, physical safety, sex reassignment surgery, alcohol and drug use, and safer sex self-efficacy. Chrysalis members and key informants cited positive adult TG role models and peer support as key factors in the program's success. (Contains 3 tables and 2 notes.)