This year marks the seventh annual EDUCAUSE Current Issues Survey to identify what campus information technology (IT) leaders see as their most critical IT challenges. Thirty-seven percent (628) of the 1,708 EDUCAUSE primary member representatives responded to an e-mail invitation to complete the Web-based survey in December 2005. Survey participants were asked to check up to five of 31 issues in response to each of four questions. In preparing the survey each year, the Current Issues Committee tries to strike a balance between preserving issue choices across time and introducing: (a) new issues that arise as a consequence of emerging technologies and new solutions; and (b) changes in the evolving IT nomenclature. For 2006, the Committee introduced these three issues: (1) End-to-End Service Assurance; (2) Outsourcing; and (3) Portfolio Development and Management. In this article, members of the Current Issues Committee describe the top-ten issues for 2006 that IT leaders say are the most important for their institutions to resolve for strategic success. These are: (1) Security and Identity Management; (2) Funding IT; (3) Administrative/Enterprise Resource Planning (ERP)/Information Systems; (4) Disaster Recovery/Business Continuity; (5) Faculty Development, Support, and Training; (6) Infrastructure; (7) Strategic Planning; (8) Governance, Organization, and Leadership; (9) E-Learning/Distributed Teaching and Learning; and (10) Web Systems and Services. (Contains 6 tables and 25 endnotes.)