This review explores evidence-based treatment for depression within the college and university population. Treatments for depression in adults are among the most rigorous studied treatment modalities in the psychotherapy literature, providing consistent evidence for the efficacy of at least two treatments, cognitive behavioral therapy and interpersonal psychotherapy for depression, but the evidence for use of these therapies within the college population is sparse and inconclusive. The length of psychotherapy, diagnostic purity, and lack of adherence to specific theoretical models may be important elements contributing to the lack of treatment research on this population. More research should be focused on developing and evaluating specific treatments, which might address some of the unique stresses and dynamics within the college population.