Many college leaders are coming to understand that, in a global economy, they need to produce graduates and develop faculty members with strong international skills. The recognition has led them to take new, more deliberate approaches to work abroad. In the past, individual faculty members have had connections with colleagues overseas, but those relationships rarely advanced beyond specific research interests and have had little institutional impact. U.S. colleges are now getting serious with partners overseas: a growing number of college leaders say they want arrangements that involve multiple departments and disciplines, square with institutional goals, and tackle global challenges like sustainable agriculture or clean energy. Universities with significant resources may focus on developing select strategic relationships; others may nurture existing faculty and department partnerships; others may need to be prepared when unique opportunities present themselves. All colleges, however, can be more thoughtful and tactical in working overseas.