The ultimate goal of teaching is to produce enlightened students. It is believed that this is possible provided that teachers approach teaching in a holistic manner that exercises the best practices. They however need to have some form of guidance to teach in this manner. The paper describes the development of a teachers guide to teaching-learning (TGTL) at upper secondary school level. It is based on a holistic conceptual framework of best practices derived from the literature and empirically. The paper is made up of three parts: the descriptions of (1) the basic concepts: of enlightenment, best practices and holistic approach, (2) the framework and a holistic model for best practices (HOBP), assessment through classroom activities and refinement and (3) the construction of the TGTL based on findings in (2). This paper however does not include the assessment and evaluation of the effectiveness of TGTL. (Contains 2 figures.)