College campuses across the United States are increasingly challenged to educate psychologically distressed students and to recognize that college student mental health is not only a counseling center issue, but also a campus issue. As such, many colleges and universities are moving toward campuswide prevention efforts designed to help identify and support students who need to manage their distress. Prior research has highlighted these issues and described ways to involve campus units in initiating campuswide prevention efforts. This article focuses on the key elements necessary to successfully foster prevention efforts and includes practical suggestions to improve prevention protocols on campus. (Contains 1 figure.)