Team-based learning (TBL) has been shown to improve student learning in a variety of settings. In a majority of cases, TBL has been implemented in face-to-face formats and occasionally in blended learning formats, which are partially online partially and face-to-face in a classroom. The Sloan Consortium surveys report a steady increase in the enrollments in online courses, and this is borne out by data gathered at the University of Texas at El Paso. Over the past five years, everyone has faced an increase in the demand for courses in flexible learning formats (blended and 100 percent online), with enrollment increasing by an average of 20 percent each year. With the unequivocal efficacy of TBL in the traditional face-to-face class format, it became imperative to find a way to implement it in flexible learning format courses. This chapter describes the implementation of asynchronous TBL in a fully online course and provides some practical strategies for practitioners interested in such implementations. (Contains 1 table and 1 figure.)