Objective: To identify the informed-consent issues when conducting adolescent health behavior research. Methods: A literature review was conducted across diverse academic fields about the informed-consent issues that were relevant to adolescent health behavior research. Results: Issues included defining consent, assent and permission, minimal risk, risk assessment; legal issues; adolescent capacity to participate in research, and parental permission. Conclusions: Integrity in research means doing the right thing. Obtaining adolescent informed consent must be obtained every time data are collected. There seem to be occasions in which waiver of parental permission in some adolescent health behavior research is warranted.