Objectives: To summarize recommendations from Youth Tobacco Cessation: A Guide for Making Informed Decisions for careful consideration, selection, implementation, and evaluation of youth cessation interventions. Methods: Recommendations were developed from an evidence review and consensus from a multidisciplinary advisory panel. Results: Identified essential elements for selecting, planning, delivering, and evaluating youth cessation interventions. Conclusions: Until there is more evidence for effectiveness of youth specific cessation interventions, clinicians and practitioners should adopt treatments that use cognitive- behavioral approaches for youth cessation interventions that require careful planning and rigorous evaluation.