Audience Response Systems (ARS) represent a powerful new tool for increasing student engagement. ARS technology (known variously as electronic voting systems, personal response systems, interactive student response systems, and classroom performance systems) includes one hand-held remote per student, a receiver (infrared or radio frequency, depending on the system), a computer for recording student responses, and a means for projecting information to the class. The author used an ARS called Qwizdom as a tool in his compulsory high school sophomore biology classes to eliminate formal lecture and note-taking, and reports on the learning gains made by his experimental group compared to gains made by students in his traditional lecture-based classes. All students experienced both lecture-free and lecture-based approaches, so he also includes student assessments of the different approaches. (Contains 2 tables and 5 figures.)