This paper describes a two-year study in which high levels of performance were achieved and sustained among so-called low-level workers in a biotech company. The purpose of the study--funded by National Science Foundation and lnvitrogen Corporation--were to explore the effectiveness of an accelerated learning Operational Simulation (OpSim) training on workers in biological manufacturing. While greater responsibility is demanded of "front-line" workers in biotech, efforts at "empowerment" have not worked well in this context. In this particular OpSim, workers were facing a large and expensive backorder problem. The OpSim did not target or specify the skills or means for greater responsiveness; rather we emphasized only goals and challenged the groups to develop a solution. All groups failed on the first try, but exceeded desired outcomes on the second try and subsequently sustained these performance objectives. Implications for Naturalistic Decision Making, training, and empowerment are discussed. (Contains 3 figures.)