This article presents the results of two studies on the applicability and use of universal design in higher education. In Study 1, the instructional climate for students with disabilities was assessed through a survey of 271 faculty members and teaching associates (TAs) and focus groups with 92 additional faculty members and TAs. Survey respondents ranked universal design for learning (UDL) as the most needed training topic. A web-based, self-paced professional development tool called FAME (Faculty and Administrator Modules in Higher Education) was developed, piloted, and revised in response to the training needs identified. In Study 2, a review of FAME by 98 faculty members and administrators supported the value of on-demand, multi-modal professional development in universal design. Ninety-two percent of respondents reported increased comfort in meeting the instructional needs of students with disabilities as a result of using this curriculum. Implications and specific guidelines for providing educational access to students with disabilities are discussed.