Objective: The authors' purpose in this study was to estimate prevalence and correlates of "Diagnostic and Statistical Manual of Mental Disorders," 4th edition ("DSM-IV"), major depressive episodes (MDEs) among Spanish university students. Participants and Methods: In October and November 2004, interviewers administered a screening tool to a sample of 554 students aged 18-34 years (65.9% women). Results: The prevalence of MDEs was 8.7% (95% confidence interval = 6.5%-11.3%). The most common symptoms were depressed mood (81.3%) and altered sleep (79.2%). MDEs were more prevalent among women than men (p less than 0.05). The mean number of previous episodes of depression among currently depressed students with previous episodes was 2.2 (SD = 1.4). Of depressed students, 0.6% had considered suicide and 0.2% had attempted suicide. Conclusions: Depression was highly prevalent among university students. The results suggest the need to develop some type of program or service for university students with the aim of preventing depression and improving their adaptation to university life. (Contains 5 tables.)