Isfahan University of Medical Sciences, as one of the major medical universities in Iran, is an academic organization which is also responsible for all health-related services in Isfahan province. By development of IT infrastructures in the university, top management decided to utilize the capabilities of the growing IT infrastructures in order to solve data and knowledge management problems. Faculty members who are the key component in academic activities are selected as the data entity and data source. This paper describes the process of building a Web-based information system to collect information related to faculty members' activities from themselves and produce an organizational knowledge base. An online faculty information system is now growing towards a nation-wide system and is available at www.ofis.ir. (Contains 1 table.)