HIV/AIDS continues to spread among children, youth, and young adults across all racial, ethnic, and cultural populations, including those with disabilities. This article considers information on HIV/AIDS such as individuals' health-risk behaviors, environmental circumstances, and perceptions that may contribute to HIV-infection; how disability characteristics, and cultural traits and values impact school-based HIV/AIDS prevention programs; and, culturally competent instructional considerations that acknowledge these variables. (Contains 4 tables.)