This paper presents a four-year longitudinal case study of a nine-year-old student when he was diagnosed with leukemia. Cognitive, neuropsychological, and affective functioning both pre and post chemotherapy treatment were assessed. Full neuropsychological evaluation revealed difficulties with processing speed, concentration, and organization following treatment. Psycho-educational interventions developed through interdisciplinary team collaboration resulted in significant reductions in these problems for the student. Implications and recommendations for all educators and multidisciplinary teammembers are discussed. (Contains 1 table.)