Objective: The purpose of this article was to examine how an initiative of 10 collaborative projects focused on children and youth have applied principles of participatory research, collaboratories, and technological solutions. Method: The study analyzed multiple forms of qualitative data, including semiannual formative evaluations and semistructured interviews of participating partners. Results: Both the collaborative method and the infusion of technology were central to the functioning of collaboratory projects and, ultimately, the translation from research to practice and policy. The community-based participatory nature of the research projects resulted in applicable findings that were credible with people affected by the issues studied. Conclusions: The present study suggests that when there is steadfast commitment on the part of a diverse group of partners, even simple applications of technology can make a difference. (Contains 1 table.)