The EDUCAUSE Advisory Committee for Teaching and Learning (ACTL) has identified the key technology-related teaching and learning issues in higher education for 2007. The 10 important teaching and learning issues are: (1) Establishing and supporting a culture of evidence; (2) Demonstrating improvement of learning; (3) Translating learning research into practice; (4) Selecting appropriate models and strategies for e-learning; (5) Providing tools to meet growing student expectations; (6) Providing professional development and support to new audiences; (7) Sharing content, applications, and application development; (8) Protecting institutional data; (9) Addressing emerging ethical challenges; and (10) Understanding the evolving role of academic technologists. Each of these top-ten teaching and learning issues is explored in this article. (Contains 5 endnotes.)