A framework, termed the RSP, is proposed. It is mainly for analyzing and explaining how learning occurs. This framework is grounded in the social-cultural perspective, in particular, in the thinking of both Vygotsky and Popper. Although the thinking of Popper is generally not referred to as having a social-cultural orientation, mostly due to misunderstanding, he and Vygotsky are defensibly complementary. In a nutshell, Vygotsky's social-cultural (inter-psychological) plane is enriched by Popper's distinction between physical and conceptual-abstract worlds, while Popper's mental world is enhanced by Vygotskian and post-Vygotskian work emphasizing personality, that is, the whole self. Integrating and expanding on both Vygotsky and Popper, the RSP framework further unpacks how learning occurs as dialectical interactions between the Worlds of reifications (R), selves (S), and phenomena (P). The World of Reifications (R) extends Popper's World 3 by emphasizing the developmental nature of conjectures to theories. The World of Selves (S) now extends Popper's World 2 from cognitive dimensions to the whole individual. And the World of Phenomena (P) extends Popper's World 1 to include the relationships between objects forming phenomena, including the physical, social, and spiritual dimensions. The interactions among the three Worlds result in five learning outcomes: cognition, metacognition, action, reflective action, and epistemic cognition. It is contended that these five outcomes are necessary criteria for holistic learning. The framework is then applied to analyzing various issues such as resolving lethal mutations, identity, and learning as becoming.