Studies examining the structural correlates of urban crime have generated a large body of research; however, few studies have linked the structural conditions to race-specific drug arrests. In this study, the authors examine the impact of urban disadvantage, social disorganization, and racial threat indicators on the rise in race-specific drug arrests from 1980 to 1990. They find these theoretical perspectives contribute to an understanding of the change in race-specific drug arrests. Findings indicate that shifts in the urban economy significantly affected Black drug arrests, while having no effect on the change in White drug arrests. In addition, the shift away from manufacturing jobs significantly affected Black arrests for drug possession. Consistent with the theory, social disorganization measures proved equally significant for Whites and Blacks, whereas mixed support was found for racial threat arguments. The importance of a theoretically grounded exploration into the rise in racial disparities in drug arrests is highlighted. (Contains 3 tables and 3 notes.)