As a school leader, what do you need to know about Response to Intervention (RTI) and your role in leading instruction for struggling learners? In this article the authors offer guidance about the content of the RTI initiative based on policy, research, and practice. They provide a brief history of the Individuals with Disabilities Education Act and No Child Left Behind Act as they pertain to special education and how RTI can help prevent underachievement. They outline a step-by-step process for implementing RTI from building a foundation to building your schoolwide leadership team. In outlining the three levels of intervention, they discuss the support school administrators can provide to teachers and specialists at each level. The authors also offer suggestions for leading schoolwide change by implementing the RTI process gradually, and providing administrative support to ensure that students--and teachers--have genuine opportunities to learn.