Cigarette smoking has been identified as the most important source of preventable morbidity and premature mortality worldwide (American Lung Association, 2002). Statistics show that youth who do smoke report having their first cigarette while in middle school, thus this is a critical opportunity for prevention (Eissenburg & Balster, 2000). This project helps expand current knowledge of adolescent smoking prevention programs by demonstrating an understanding of adolescents' preference for and acceptability of the Internet in the delivery of a smoking prevention intervention. A qualitative usability study was conducted among middle school students using focus groups. Results found that the Internet is a good choice for delivery of a prevention program due to its accessibility, including the availability in most schools. Elements of interactivity and expert-trusted guidance were identified as appealing. In addition, the use of pictures and graphics in conjunction with text, can be useful in reaching students with varied learning styles. By using this non-traditional approach, health education and promotion can work in parallel with the schools, parents, and community in the delivery of effective smoking prevention programs delivered via the Internet. [Abstract is provided in both English and Spanish.]