In this article, the author discusses how it is time for higher education to think seriously about alternatives to the traditional undergraduate "major," which, in the large majority of cases, tends to be focused on just a single field of inquiry. The author observes that the current idea of a major (or minor) subject may have made more sense in a less complex and interconnected world in which the perspective and method of one discipline could be applied to a fairly confined and narrow problem. However, in today's world, few problems of any significance are either confined or narrow. In order to prepare students to have the skills in facing the outside world after they graduate, the author suggests adoption of problem-based learning. The author also presents six principles for the construction of a problem-based major or minor curriculum.