Why people move, their well-being or self-assessed quality of life and the impact that this has on the stability of neighbourhoods are linked in many ways. One of the expected outcomes related to the attachment to and meaning of place is the level of intra-urban mobility by individuals and families. Those who have negative or neutral feelings towards the place they reside are expected to experience a greater level of intra-urban mobility. The objective of this paper is to examine the relationship between residential mobility and perceived well-being or self-assessed quality of life in Saskatoon, Saskatchewan across three clusters of neighbourhoods representing different socio-economic status (SES) (low, middle and high). The paper begins with a review of the literature on residential mobility and highlights concepts such as the life-cycle, social cohesion and social isolation. It employs data from three sources: a telephone survey collected from residents in 2001, a series of face-to-face interviews and 2001 Census data. The data are analysed statistically using a mixed model approach. The results show that mobility is an important feature of Saskatoon, and that a significant difference exists in the length of residency among the three neighbourhood clusters. However, the analysis indicates that there is no relationship between residential mobility and well-being as measured by self-reported quality of life and health.