The phenomenon of drug craving among adolescents with substance use disorders has been largely overlooked by addiction researchers. This study was designed to: (1) assess craving among adolescents with polysubstance use disorders (SUDs); and (2) examine the association between personality traits and craving among adolescents with SUDs. Craving was found to be a multidimensional phenomenon that demonstrated some degree of consistency across substances (in this case, marijuana and alcohol). Selected personality traits were associated with distinct components of craving; for example, adolescent substance users who obtained high sensation-seeking scores tended to crave the excitement associated with drug use. Adolescents who obtained high anxious-neuroticism scores tended to crave the experience of distress relief associated with drug use.