The purpose of this study was to determine the effects of teaching eight secondary students with disabilities, including seven with learning disabilities, a strategy for answering a variety of inferential questions. A multiple-baseline across-subjects design was employed. Outcome measures included scores on researcher-devised comprehension quizzes, a standardized test of reading comprehension, a strategy use test, a strategy knowledge test, and a reading satisfaction measure. Fidelity of implementation, instructional time, and maintenance of skills were also measured. Results suggest that students with disabilities can learn to use a strategy to answer a variety of inferential questions, and mastery of its use can result in improved scores on criterion-based and standardized measures of reading comprehension. In addition, students' satisfaction with their reading improved. (Contains 6 tables and 4 figures.)