Peer-mediated instruction holds particular promise as an effective educational strategy for children with learning disabilities. When properly implemented, peer-mediated instructional approaches permit active engagement, frequent opportunities to respond, immediate error correction, prompt feedback on the correctness of responses, and motivational elements. They promote the integration and acceptance of children with disabilities. Here, research on 3 peer-mediated instructional approaches shown to be effective in promoting the academic achievement of children with learning disabilities is described. Guidelines for implementation, research findings, and practical considerations for success are discussed.