Because of recent advances in medications and treatment regimens, persons with HIV disease are maintaining better health status and living longer. Thus, greater opportunities exist for these individuals to either continue their current employment or return to the world of work. The purpose of this qualitative study was to provide in-depth descriptions of related vocational experiences of persons with HIV. Data were collected from eight focus groups consisting of a diverse sample of people living with HIV (N = 93). Results support the need for counseling psychologists and other mental health professionals to address real and perceived barriers, both internal and contextual, while also becoming advocates for persons with HIV who want to work. A model derived from qualitative data analysis provides visual representation of the work experiences of people living with HIV, for potential application in assessment and treatment. (Contains 1 figure and 1 table.)