This article provides a brief overview of CASAWORKS for Families (CWF), an innovative intervention designed to help substance-abusing parenting women on welfare. CWF was developed in response to the passage of welfare reform legislation in 1996. Factors that provided a background and context for the development of CWF are considered. The rationale, key elements, and the conduct of a pilot demonstration of CWF are described. Evaluation findings that serve to guide the next steps to improve the intervention are reviewed. Finally, new welfare policy priorities emerging around the importance of addressing behavioral health problems among welfare recipients are highlighted.