The rationale for the use of logotherapy in the context of substance use treatment is introduced. The article reviews prior group applications of logotherapy and offers a clinical curriculum for a group application of logotherapy tailored to the substance use treatment context. Furthermore, the article provides a discussion of the specifics of the group format and role induction to the "Meaning of Life" group, as well as a detailed discussion of eight themes that constitute the proposed logotherapeutic group intervention for substance use population.